AICF's 2020-21 Fellow:
Alice Meroni, PhD
Unravel the mechanism of Topoisomerase I inhibitor resistance
"My project is focused on the resistance pathways activated by cancer cells in response to camptothecin. Camptothecin inhibits selectively Topoisomerase I, a key enzyme that regulates DNA topology, and is the prototype of a class of compounds widely used for cancer treatment. Thanks to the AICF support, I identified an uncharacterized pathway implicated in camptothecin resistance. In year 2, I will study the key factors involved in this pathway and define the molecular steps that lead to resistance. My data will provide a new rationale to overcome chemotherapy resistance in cancer cells treated with multiple cycles of Topoisomerase I-inhibitors."